Week 2 NFL picks, odds, 2023 best bets from advanced model: This 5-way football parlay pays 25-1

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Detroit opened the season with a statement win at Kansas City, pulling off the upset as a four-point road underdog. The Lions scored the game-winning touchdown with just over seven minutes remaining, holding Kansas City scoreless the rest of the way. They are 5.5-point favorites against Seattle according to the latest Week 2 NFL odds from SportsLine consensus. Seattle is coming off a 30-13 loss to the Rams, so should you include the Lions in your Week 2 NFL bets?

Meanwhile, Kansas City will try to avoid a 0-2 start when it travels to Jacksonville on Sunday. The Chiefs are 2.5-point favorites in the Week 2 NFL spreads and will hope to have star tight end Travis Kelce (knee) back on the field. Before you make any Week 2 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 1 of the 2023 NFL season on an incredible 163-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 17-6 roll on top-rated NFL picks since Week 7 of this season.  

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 2. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 2 NFL picks at SportsLine.

Top Week 2 NFL picks

After simulating every game 10,000 times, the model is high on the Tampa Bay Buccaneers (-3) to cover at home against the Chicago Bears. The Bears were one of the league’s most talked-about teams entering the season, but they did not meet expectations in Week 1. They never led in their 38-20 loss to Green Bay despite entering the game as 1.5-point favorites.

Quarterback Justin Fields threw an interception and was sacked four times, while Chicago’s defense allowed 329 total yards. Tampa Bay is feeling much better after the first week of the season, beating Minnesota outright as a four-point road underdog. Buccaneers quarterback Baker Mayfield is projected to throw for almost 300 yards and two touchdowns against Chicago in the model’s latest simulations, one reason why Tampa Bay covers the spread well over 50% of the time. See which other NFL parlay picks to make here.

How to make Week 2 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including three underdogs that have a chance to win outright. You can only see the model’s NFL Week 2 best bets and parlay at SportsLine. 

What are the model’s top Week 2 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from a model on a 163-113 run on its top-rated picks, and find out.

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