The Week 1 NFL schedule is loaded with high-profile NFL matchups and tight NFL spreads, including four battles between playoff teams from a season ago and three divisional rivalry games. Jim Harbaugh will begin his Chargers coaching career on Sunday when L.A. hosts the Las Vegas Raiders for an AFC West matchup. The Chargers had to make salary-cap concessions this offseason, but they still have quarterback Justin Herbert and now have a coach who has won consistently. Los Angeles is a three-point favorite in the Week 1 NFL odds according to the SportsLine Consensus. Which side should you back in that contest and which teams should you favor as you make your Week 1 NFL predictions? Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.
For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.
Top Week 1 NFL AI picks
After analyzing every game in Week 1, the AI PickBot says the Broncos cover as 5.5-point underdogs against the Seahawks in a game that has earned an A-rated pick. Denver went 5-12 in 2022 and got off to a 1-5 start in Sean Payton’s first year at the helm, but his team clearly started buying in later in the season. The Broncos went on a five-game winning streak in the middle of the season and ended up finishing a respectable 8-9 after the tough start.
However, oddsmakers seem to be significantly discounting the improvement shown, setting their over/under at six wins for 2024 and spotting them 5.5 points in Week 1, making them the third-biggest underdogs of the week. Meanwhile, they seem to be overestimating a Seahawks squad that started 5-2 but lost six of 10 to miss the playoffs. The AI PickBot is predicting the Seahawks win, but only by an average final score of 21.86-20.34, which puts the Broncos comfortably within the margin for error at +5.5. See its other Week 1 football predictions and football picks at SportsLine.
How to make Week 1 NFL picks
In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot’s analysis before making any Week 1 NFL bets. You can only see it at SportsLine.
Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.
